C. Rochat, N. Bernard-Marissal, S. Pradervand, Perrin F.E., C. Raoul, P. Aebischer and B.L. Schneider.  Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and improves neuromuscular function in a mouse model of amyotrophic lateral sclerosis. Pub Med

C.M. Bringuier, H.N. Noristani, M. Cardoso, C. Goze-Bac, Y.N. Gerber* and F.E Perrin*. Upregulating astrocytic fgfr4 expression in adult mice promotes functional recovery after spinal cord injury.

Perez JC, Gerber Y.N. and F.E. Perrin. Dynamic diversity of glial response among species in spinal cord injury. Frontiers in Aging Neuroscience. Pub Med

R. Chevreau, H. Ghazale, C. Ripoll, C. Chalfouh, Q. Delarue, A.L. Hemonnot-Girard, H. Hirbec, S. Wahane, F.E. Perrin, H.N. Noristani, N. Guerout and JP. Hugnot. Reaction of ependymal cells to spinal cord injury: a potential role for oncostatin pathway and microglial cells. Pub Med



V. Paschon,F.  Fernandes Correia, B. Cintra Morena, V. A. da Silva, G. Bispo dos Santos, M.C. Carlan da Silva, A. Fogaça Cristante, Willerth, F.E. Perrin and Hiroaki Kihara (2019).
CRISPR, prime editing, optogenetics and DREADDs: new therapeutic approaches provided by emerging technologies in the treatment of spinal cord injury.
Molecular Neurobiology, Apr;57(4):2085-2100. doi: 10.1007/s12035-019-01861-w. Pub Med


*A. Lattard, *G. Poulen, S. Bartolami, †Y.N. Gerber and †F.E.Perrin (2021). Negative impact of Sigma-1 receptor agonist treatment on tissue integrity and motor function following spinal cord injury. Frontiers in Neuroanatomy Neuropharmacology, doi: 10.3389/fphar.2021.614949. eCollection 2021. Pub Med

G. Poulen, E. Aloy, C.M. Bringuier, N. Mestre-Francés, E.V.F. Artus, M. Cardoso, J-C. Perez, C. Goze-Bac, N. Lonjon, H. Boukhaddaoui, Y.N. Gerber† and F. E. Perrin† (2021). “Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and nonhuman primates” Theranostics, Vol. 11, Issue 18, 8640-59 Pub Med

G. Poulen*, Y.N.Gerber*, J-C. Perez, K. Oubarrahou, N. Lonjon, F. Vachiery-Lahaye, H. Boukhaddaoui, and F.E. Perrin (2021). Coherent anti-stokes Raman scattering microscopy: a label free method to compare spinal cord myelin in different species. Frontiers in Physics Optics and Photonics, doi: 10.3389/fphy.2021.6656509.

 L. Bauchet, G. Poulen, N. Lonjon, F. Vachiery-Lahaye, E. Bourinet, F.E. Perrin, J.P. Hugnot. Isolation and Culture of Precursor Cells from the Adult Human Spinal Cord. Methods Mol Biol. 2022;2389:103-110. doi: 10.1007/978-1-0716-1783-0_10. Pub Med




F.E. Perrin and H.N. Noristani (2019).
Serotonergic Mechanisms in Spinal Cord Injury.
Experimental Neurology, Pub Med

H; Ghazale, C. Ripoll, N. Leventoux, L. Jacob, S. Azar, D. Mamaeva, Y. Glasson, C.F. Calvo, J.L. Thomas, S. Meneceur, Y. Lallemand, V. Rigau, F.E. Perrin, H.N. Noristani, B. Rocamonde, E. Huillard, L. Bauchet and J.P. Hugnot (2019).
RNA profiling of the human and mouse spinal cord stem cell niches reveals an embryonic-like dorsal-ventral regionalization with MSX1+ roof-plate-derived cells.
Stem Cell Reports, S2213-6711(19)30100-6. doi: 10.1016/j.stemcr.2019.04.001. Pub Med

H.N. Noristani and F.E. Perrin (2019).
Use of longitudinal magnetic resonance imaging in preclinical models of spinal cord injury.
Editorial Neural Regeneration Research, 14(5):771-772. doi:10.4103/. Pub Med

*Y.N. Gerber, *G.P. Saint-Martin, C.M. Bringuier, S. Bartolami, C. Goze-Bac, H.N. Noristani and F.E. Perrin (2018).
CSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord Injury.
Frontiers in Cellular Neurosciences, Oct 16;12:368. doi: 10.3389/fncel.2018.00368. eCollection 2018. Pub Med

H.N. Noristani, L. They and F. E. Perrin (2018).
C57BL/6 and Swiss Webster mice display differences in mobility, gliosis, microcavity formation and lesion volume after severe spinal cord injury.
Frontiers in Cellular Neurosciences, 12:173.doi: 10.3389/fncel.2018.00173. Pub Med

G. Poulen and F.E. Perrin (2018).
Microcebus murinus: a novel promising non-human primate model of spinal cord injury.
Editorial Neural Regeneration Research, doi:10.4103/1673-5374.228721. Pub Med

H.N. Noristani, G.P. Saint-Martin, M. Cardoso, M. Catteau, R. Sidiboulenouar, C. Coillot, C. Goze-Bac and F. E. Perrin
Longitudinal MRI analysis and histological characterisation after spinal cord injury in two mouse strains with different functional recovery : gliosis as a key factor.
Journal of Neurotroma, doi: 10.1089/neu.2017.5613. Pub Med

M. Le Corre, H.N. Noristani, N. Mestre-Frances, G.P. Saint-Martin, C. Coillot, C. Goze-Bac, N. Lonjon and F.E. Perrin
A novel translational model of spinal cord injury in non-human primate: multi-scale correlations from behaviour to magnetic resonance imaging.
Neurotherapeutics, Jul;15(3):751-769. doi: 10.1007/s13311-017-0589-9. Pub Med

S. Salinas, O. Constant, C. Desmetz, J. Barthelemy, J.M. Lemaitre, O. Millhavet, N. Nagot, V. Foulongne, F. E. Perrin, J.C. Saiz, S. Lecollinet, P. Van de Perre and Y. Simonin 2017.
Deleterious effect of Usutu virus on human neural cells.
PLOS Neglected Tropical Diseases, Sep 5;11(9):e0005913. doi: 10.1371/journal.pntd.0005913. eCollection 2017 Sep. Pub Med

 T. Berta, F. E. Perrin, M. Pertin, R. Tonello, Y.C. Liu, A. Chamessian, A.C. Kato, R.R. Ji, I. Decosterd 2017.
Gene expression profiling of cutaneous injured and non-injured nociceptord in SNI animal model of neuropathic pain.
Scientific Reports, 7:9367. DOI:10.1038/s41598-017-08865-3. Pub Med

H. N. Noristani, H. Boukhaddaoui, G.P. Saint-Martin, P. Auzer, R. Sidiboulenouar, N. Lonjon, E. Alibert, N. Tricaud, C. Goze-Bac, C. Coillot and F. E. Perrin 2017.
Microglial alterations after spinal cord injury: a combination of ex vivo diffusion MRI and multiphoton study.
Frontiers in Aging Neurosciences, 9:230. doi: 10.3389/fnagi.2017.00230. Pub Med

H. Hirbec, H. N. Noristani and F. E. Perrin 2017.
Microglia responses diversity in acute and chronic neurological diseases: what microglia-specific transcriptomic taught (and did not teach) us.
Frontiers in Aging Neuroscience, 9:227.doi: 10.3389/fnagi.2017.00227. Pub Med

H.N. Noristani , Y.N. Gerber, J.C. Sabourin, M. Le Corre, N. Lonjon, N. Mestre-Frances, H. Hirbec and F. E. Perrin 2017.
RNA-Seq analysis of microglia reveals time-dependent activation of specific genetic programs following spinal cord injury.
Frontiers in Molecular Neuroscience, 10:90. doi: 10.3389/fnmol.2017.00090. Pub Med

H.N. Noristani and F. E. Perrin 2016.
Astrocyte-to-neuron conversion induced by spinal cord injury
Editorial Oncotargets, Advance on line publication. doi: 10.18632/oncotarget.13780 Pub Med

H.N. Noristani, J.C. Sabourin, H. Boukhaddaoui, E. Chan-Seng, Y.N. Gerber and F. E. Perrin 2016.
Spinal cord injury induces astroglial conversion towards neuronal lineage.
Molecular Neurodegeneration, 2016 Oct 6;11(1):68. Pub Med

Coillot, Sidiboulenouar, Nativel, Zanca, Alibert, Saint Martin, H.N. Noristani, N. Lonjon, F.E. Perrin, and Goze-Bac 2016.
Signal Modeling of a MRI Ribbon Solenoid Coil Dedicated to Spinal Cord Injuries Investigations.
J. of Sensors and Sensor Systems. 5, 137-145. journal of sensors and sensor systems

Do-Thi A, Perrin FE, Desclaux M, Saillour P, Amar L, Privat A, Mallet J 2016.
Combination of grafted Schwann cells and lentiviral-mediated prevention of glial scar formation improve recovery of spinal cord injured rats.
The Journal of Chemical Neuroanatomy. 76(Pt A):48-60. doi: 10.1016/j.jchemmneu.2015.12.014. PubMed

*H.N. Noristani, *N. Lonjon, M. Cardoso, M. Le Corre, E. Chan Seng, G. Captier, A. Privat, C. Coillot, $C. Goze-Bac and $F. E. Perrin. 2015.
Correlation of in vivo and ex vivo 1H-MRI with histology in two severities of mouse spinal cord injury.
Frontiers in Neuroanatomy, doi: 10.3389/fnana.2015.00024. Pub Med.

Deleyrolle, Sabourin, Rothhut, Fujita, Guichet, Teigell, Ripoll, Chauvet, F.E. Perrin, Mamaeva, Noda, Mori, Yoshihara and Hugnot. 2015.
OCAM regulates embryonic spinal cord stem cell proliferation by modulating ErbB2 receptor.
PloS One, Apr 13;10(4):e0122337. doi: 10.1371/journal.pone.0122337. Pub Med

M. Desclaux, F.E. Perrin, A. Do-Thi, M. Prieto-Cappellini, M. Gaviria, M. Giménez y Ribotta, J. Mallet and A. Privat. 2015.
Lentiviral-mediated silencing of GFAP and vimentin in reactive astrocytes improves functional recovery and axonal plasticity after spinal cord injury.
Journal of Neuroscience Research. 93(1):43-55. Pub Med

*H.N. Noristani, *J.C. Sabourin, Y.N. Gerber, M. Teigell, A. Sommacal, MdM. Vivanco, M. Webber and F. E. Perrin. 2015.
Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS.
Molecular Neurodegeneration, 10:34, doi:10.1186/s13024-015-0023-x. Pub Med



N. Lonjon, P. Kouyoumdjian, M. Prieto, L. Bauchet, H. Haton, M. Gaviria, A. Privat and F.E. Perrin. 2010.
Early functional outcomes and histological analysis after spinal cord compression injury in rats. PubMed
Journal of Neurosurgery: Spine.

F.E. Perrin, G. Boniface, C. Serguera, N. Lonjon, A. Serre, M. Prieto, J. Mallet and A. Privat. 2010.
Grafted human neural stem cells expressing neurogenin 2 stimulate axonal sprouting and improve functional motor recovery after severe spinal cord injury. PubMed
PloS One, 5(12): e15914.

N. Lonjon, G. Boniface, R. Feifel, R. Endres, M. Giménez y Ribotta, A. Privat and F.E. Perrin. 2011.
Potential adverse effects of Cyclosporin A on Kidneys after Spinal Cord Injuries.
Spinal Cord, 49(3):472-9. Pub Med.

E. Chan-Seng, F.E. Perrin, F. Segnarbieux, N. Lonjon.
Diving-induced cervical spine injuries: a 10-year retrospective descriptive study.
Orthopaedics & Traumatology: Surgery & Research. 99(5):607-13. Pub Med.

F.E. Perrin, Y.N. Gerber, G. Boniface, M. Teigel, L. Bauchet, and A. Privat. 2011.
Anatomical study of serotoninergic innervation and 5HT1A receptors in human spinal cord.
Cell Death and Disease. 2:e218. Pub Med.

D. Mamaeva, C. Ripoll, C. Bony, F.E. Perrin, M. Teigell, I. Bieche, R. Lidereau, A. Privat, V.e Rigau, H. Guillon, D. Noel, L. Bauchet and J. P. Hugnot 2011.
Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord.
BMC Neuroscience. 10;12(1):99. Pub Med.

Lonjon N., Privat A., Bauchet L., Perrin F. E. 2012.
Research in Acute Traumatic Spinal Cord Injuries : Progresses and Prospects.
Orthopedic & Muscular System: Current research. doi: 10.4172/2161-0533.S1-002.

Y.N. Gerber, J.C. Sabourin, M. Rabano, M.D. Vivanco and F. E. Perrin. 2012.
Early functional deficit and microglial disturbances in a mouse model of amyotrophic lateral sclerosis.
PloS One. 7(4): e36000. Pub Med.

Y. N. Gerber, JC Sabourin, JP Hugnot, and F. E. Perrin. 2012.
Unlike physical exercise, modified environment increases the lifespan of SOD1G93A mice however both conditions induce cellular changes.
PloS One. 7(9):e45503. Pub Med.

N. Lonjon, F. E. Perrin, M. Lonjon, C. Fattal, F. Segnarbieux, A. Privat and L. Bauchet.
Acute Traumatic Spinal Cord Injuries: Epidemiology and Prospects.
Neurochirurgie. 58(5):293-9. doi: 10.1016. Pub Med.



F.E Perrin, S. Lacroix, M. Aviles Trigueros and S. David (2005)
Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1a and interleukin-1b in Wallerian degeneration.PubMed

N. Lonjon, M. Prieto, H. Haton, C. B. Brøchner, L. Bauchet, V. Costalat, A. Privat, M. Gaviria and F. E. Perrin (2009)
Minimum information about animal experiment: supplier is also important. PubMed
Journal of Neuroscience Research

L. Bauchet, N. Lonjon, F.E. Perrin, C. Gilbert, A. Privat and Charles Fattal (2009)
Repair strategies and functional restoration of the injured spinal cord.PubMed
Annales de Réadaptation et de Médecine Physique

Y.N. Gerber, J.P. Hugnot, L. Bauchet, F.E. Perrin and A. Privat (2009)
Stem cells: therapeutical interest in neurological pathologies.
Médecine Thérapeutique

P. Kouyoumdjian, N. Lonjon, M. Prieto, H. Haton, A. Privat, G. Asencio, F.E. Perrin and M. Gaviria (2009)
A remotely controlled model of spinal cord compression injury in mice: toward real-time analysis. Pubmed.
Journal of Neurosurgery: Spine

F. Casas, L. Pessemesse L, Grandemange S, P. Seyer, O. Baris, N. Gueguen, C. Ramonatxo, F. Perrin, Fouret G, Lepourry L, Cabello G and Wrutniak-Cabello C (2009)
Overexpression of the Mitochondrial T3 Receptor Induces Skeletal Muscle Atrophy during Aging. Pubmeb

Privat A., Perrin F.E., Mallet J. and Serguera C. (2009).
Restoration of function in spinal cord injured rats after transplantation of stem cells.
Journal of Neurochemistry.110 (supplement 2): 151.

M. Ferrer-Alcon, C. Hirt, F.E. Perrin and A.C. Kato (2008)
Physical training attenuates disease progression and stimulates cell proliferation in the spinal cord of a mouse model of motoneuron disease.PubMed

C. Dromard, H. Guillon, V. Rigau, C. Ripoll, J.C. Sabourin, F.E. Perrin, F. Scamps, S. Bozza, P. Sabatier, N. Lonjon, H. Duffau, F. Vachiery-Lahaye, M. Prieto, C. Tran Van Ba, L. Deleyrolle,  A. Boularan, K. Langley, M. Gaviria, A. Privat, J.P. Hugnot and L. Bauchet (2008)
Adult human spinal cord harbours neural precursor cells that generate neurons and glial cells in vitro.PubMed
Journal of Neuroscience Research

Simonin, F.E. Perrin and A.C. Kato (2007)
Axonal involvement in the Wlds neuroprotective effect : analysis of pure motoneurons of a mouse model protected from motoneuron disease at a pre-symptomatic age.PubMed
Journal. of Neurochemistry

M. Ferrer-Alcon, C. Hirt, F.E. Perrin and A.C. Kato (2007)
Grafted neural stem cells increase the life-span and protect host motoneurons in pmn mice.PubMed

F. E. Perrin, G. Boisset, A. Lathuilière and A. C. Kato (2006)
Cell death pathways differ in several mouse models with motoneuron disease : analysis of pure motoneuron populations at a pre-symptomatic age. PubMed
Journal. of Neurochemistry

F.E. Perrin, G. Boisset, M. Docquier, O. Schaad, P. Descombes, and A. C. Kato (2005)
No widespread induction of cell death genes occurs in pure motoneurons in an ALS mouse model. PubMed
Human Molecular Genetics



Perrin F.E., Rathjen F.G., and Stoeckli E.T. (2001)
Distinct subpopulations of sensory afferents require F11 or axonin-1 for growth to their target layers within the spinal cord of the chick.PubMed

D. Perrelet, F.E. Perrin, P. Liston, R.G. Korneluk, A. MacKenzie, M. Ferrer-Alcon and A.C. Kato (2004)
Motoneuron Resistance to Apoptotic Cell Death In Vivo Correlates with the Ratio between X-Linked Inhibitor of Apoptosis Proteins (XIAPs) and Its Inhibitor, XIAP-Associated Factor 1. PubMed
Journal of Neuroscience

E.T. Stoeckli, F.E. Perrin,T. Burstyn-Cohen, et al. (1999).
Molecular mechanisms of commissural axon guidance.
Journal of Neurochemistry. 73 (supplement) S111.

Perrin F.E. and Stoeckli E.T. (2000)
Use of Lipophilic Dyes in Studies of Axonal Pathfinding In Vivo.PubMed
Microscopy Research and Techniques

Perrin F.E. and Stoeckli E.T. (2000)
The cell adhesion molecules axonin-1 and F11 affect the axonal pathfinding of different subpopulations of sensory afferents in the spinal cord in vivo.
European Journal of Neuroscience. 12 (Supplement):179


General audience

A Privat and F.E. Perrin. 2015.
Reconstruire la moelle épinière.

Pour la Science. Pour la Science.

F.E. Perrin. 2011.
Greffer pour régénérer (transplantation for regeneration). 
Biofutur 332 : 46-49. Biofutur.